College of medicine and health science is one of the newly established colleges of Wollo University in Dessie campus. The college was established in 2008 with the objective of recruiting community minded, responsible and intelligent individuals and train them to serve their community as highly qualified health professionals. The college started its teaching activities by enrolling over 180 undergraduate degree students on regular programs in four academic departments (nursing, medical laboratory technology, environmental health and pharmacy).

The college has now 70 academic staff members and its current enrolment is well over 1000 undergraduate degree students in both regular and continuing and distance education programs. Before it was renamed as college of medicine and health science after the BPR restructuring, it is known as faculty of health science.

Subsequent to restructuring in 2009, the college is planned to expand and has prepared to open some more departments: Health officer, medicine, ophthalmic officer, midwifery nursing, Anaesthesia, Radiography, and psychiatry. The college has already four functional academic departments (nursing, medical laboratory technology, environmental health and pharmacy); where as health officer and medicine are about to be launched soon.

The college is currently accepting for distance and continuing programs from those who are interested in becoming highly trained health professional who have completed high school or preparatory colleges from natural science streams hold a diploma or degree in science related courses.

College of health science and medicine is offering a standard of medical education by making sure that a complete set of resources available to its students. Moreover, one governmental referral hospital, three private hospitals, and various health centres and regional laboratories are available for the practical activities of medical students.

The college, therefore, recognize a target mission to transmit, develop, disseminate and preserve knowledge relevant to the solution of basic problems of health and development through student centred quality teaching, research and scholarship combined with creative application of existing knowledge and provision of services to the wider community.